DISRUPT aims at revolutionising the field of biomedical imaging by developing a radically new lab-a-on-chip technology: integrated tomographic microscopy. This unprecedented technique will be enabled by pushing forward the science of on-chip wireless photonics and tomography, in combination with microfluidics and artificial intelligence (AI). The CMOS compatibility of this technology will represent a paradigm shift as it assures the realization of tomographic microscopes that are dramatically cheaper, lighter, and smaller than current approaches. Moreover, the singular features of the proposed solution will introduce key advantages in terms of resolution, sensitivity, throughput, parallelisation, and energy efficiency. To illustrate its potential, we will show that on-chip tomographic phase microscopy (TPM) can be used for cancer detection and the identification of infected cells. This novel device will be suited for many applications, such as early cancer diagnosis, cell characterisation, research on cancer and infectious diseases, immunocyte phenotyping, stem cell multipotency identification, tissue pathology, haematopathology, and analysis of infected cells. Its intrinsic mass-producible, compact, low-cost, mechanically robust, and energy-efficient feature will make this technology a future innovation driver for new developments in many biomedical application fields, and offers an alternative toolset addressing some of the emerging needs of microscopic analysis and diagnostics in low-resource settings, telemedicine applications and point-of-care, having a potentially huge societal impact fostering early diagnosis of cancer and other diseases and infections.

The proposed technology in DISRUPT will spark the development of the first on-chip photonic tomographic microscope. This integrated device will pave the way to the universalisation and quick access to advanced bioimaging techniques at all healthcare centres, enabling mass screening for early diagnostics in cancer and infectious diseases thanks to the mass manufacturability of the TPM microscope, which is not possible with previous approaches. This feature will set out a drastic reduction of the cost, weight, and size of the device, enabling field-portable TPM for point-of-care (PoC) testing and telemedicine.

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Development of the first on-chip wireless photonics platform for visible light

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Development of the first diffraction tomography theory for moving samples and a circular detector

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Development of the first on-chip holographic detector

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First on-chip TPM detection of urological and gynaecological cancer tumour cells based on liquid biopsy and identification of infected cells

Project Coordination. Design of the nanophotonic subsystems, the nanoantennas and the diffraction tomography theory. Assembly of the electronics of the final demonstrators.

Infected cells clinical validation of the final TPM demonstrator. Specification of the system requirements. Design of the microfluidic subsystem and the diffraction tomography algorithms.

Nanofabrication and laboratory test of all the photonic devices and subsystems. Design of the AI algorithms for the classification of the cellular targets.

Design, fabrication, and assembly of the microfluidic subsystem, including the valving and pumping electronic subsystems.

The most relevant polytechnic University of Spain. Alma mater of NTC and CVBLab

Urological cancer clinical validation of the final TPM demonstrator. Specification of the system requirements and end-user coaching.

Design of the AI algorithms for the classification of the cellular cells.

Gynaecological cancer clinical validation of the final TPM demonstrator. Specification of the system requirements and end-user coaching.

Deliverables
Journal Papers

DELIVERABLES

  • TBD

JOURNAL PAPERS

  • TBD

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